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Topiramate
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Topiramate

Topiramate is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

Similar Products:
Tritazide, Xedenol, Cicladol, Teval, Verapamil, Vesparax, Duvanta, Climadan, Neurolax, Metazol, Lamolep, Mazepine, Elavil, Avastatin, Spironolattone, Adiva, Uniprofen, Sesaren, Repam, Fexidine, Julphamox, Hartam, Esomezol, Ilosone, Genozym, Bazetham, Lamez, Epifenac, Pepticum,

Topiramate comes as a tablet, a sprinkle capsule (capsule that contains small beads of medication that can be sprinkled on food), and an extended-release (long-acting) capsule to take by mouth. The tablets and sprinkle capsules are usually taken with or without food once or twice a day. The extended-release capsules are usually taken with or without food once a day. Take topiramate at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take topiramate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

There is another medication with a name similar to the brand name for topiramate. You should be sure that you receive topiramate and not the similar medication each time you fill your prescription. Be sure that the prescription your doctor gives you is clear and easy to read. Talk to your pharmacist to be sure that you are given topiramate. If you think you were given the wrong medication, talk to your pharmacist. Do not take any medication unless you are certain it is the medication that your doctor prescribed.

Topiramate tablets have a bitter taste so you should swallow them whole. It is especially important that you not take topiramate tablets that have been broken for any length of time because tablets that are broken may lose their effectiveness over time.

The sprinkle and extended-release capsules (Qudexy XR brand only) may be swallowed whole or opened and poured over soft food. Swallow extended-release capsules (Trokendi XR brand only) whole; do not split, chew, or sprinkle on food.

To take the sprinkle capsules or extended-release capsules (Qudexy XR brand only) with food, follow these steps:

  1. Prepare a teaspoonful of soft food such as applesauce, custard, ice cream, oatmeal, pudding, or yogurt.
  2. Hold the capsule upright over the food.
  3. Twist off the top of the capsule and pour the entire contents onto the spoonful of food.
  4. Swallow the entire mixture immediately without chewing.
  5. Drink fluids right after swallowing to wash down the mixture and to be sure that you swallow all of it.

Your doctor will probably start you on a low dose of topiramate and gradually increase your dose, not more than once every week.

Topiramate may control your seizures or migraines but will not cure your condition. Continue to take topiramate even if you feel well. Do not stop taking topiramate without talking to your doctor, even if you experience side effects such as unusual changes in behavior or mood. If you suddenly stop taking topiramate, you may have severe seizures, even if you have not had seizures in the past. Your doctor will probably decrease your dose gradually.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with topiramate and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs) or the manufacturer's website to obtain the Medication Guide.

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Alternative tactics for improving phosphorus nutrition in crop production are needed in China and elsewhere, as the overapplication of phosphatic fertilizers can adversely impact agricultural sustainability. By integrating genetic and structural data, we employ network modeling to dissect mechanisms of kinase drug sensitivities to oncogenic EGFR mutations. (-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 via Stat3 in gastric cancer. Exposure to these drugs resulted in DNA damage, apoptosis and massive follicle loss along with a concurrent decline in the steroidogenic activity of the samples. In total, 350 women with primary breast cancer had eight bone marrow aspirates examined with antibody to epithelial membrane antigen.

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First Chemical Analysis and Characterization of the Male Species-Specific Cephalic Labial-Gland Secretions of South American Bumblebees. A phenomenological hermeneutic approach was chosen to illuminate meaning. Reasons why smokers do not seek clinic help to quit smoking need further exploration. This laboratory has identified strategies by which combinations of dietary phytochemicals may be configured to synergistically strengthen immunoregulatory mechanisms that normally prevent inflammation from leading to disease. These results demonstrate, using 2-DE, that at least two distinct forms of catechol-O-methyltransferase are present in rat brain.

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Experimental measurements of the exact mass and isotopic peak ratios made using typical peptides demonstrate the feasibility of the approach. Face recognition was measured over multiple exposures in 52 young adults ranging from low to high in social inhibition, a core dimension of social anxiety. Using the risk of symptomatic malaria once parasitemic as an outcome may improve detection of associations between immune responses and protection from disease. Invertebrate animals have been a cornerstone of basic research efforts to dissect the genetics of metabolism and nutrient response. With repeated tobacco use, the latency to withdrawal shrinks from as long as several weeks to as short as several minutes.

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As such, XOI holds a potentially dual mechanism for the treatment of cardiovascular disease. The series represents twenty patients who all presented to our institution with a diagnosis of patellar nonunion irrespective of their initial treatment. The intraspecific variability of the quality of dandelion seed progeny was greatly increased under conditions of low doses of chronic irradiation. We also determined the Brownian diffusion coefficient of BCRs from the same B cells before and after BCR engagement. Resolving the conflict: implantable cardioverter-defibrillator shocks for ventricular tachyarrhythmias increase mortality.

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The possibility of a fully automated procedure for radiosynthesis of fluorine-18-labeled fluoromisonidazole using a simplified single, neutral alumina column purification procedure. I conclude with a brief discussion of the implications of the Judgment for the International Convention on the Regulation of Whaling, and the International Whaling Commission in particular, for other international treaties, and for the interaction of science and law more generally. We prospectively investigated the role of (18)F-choline (FCH)-PET/CT in patients receiving enzalutamide after docetaxel. We took a transcriptomics approach to identify parasitic plant genes associated with host factor recognition and haustorium signaling and previously identified a gene, TvPirin, which is transcriptionally up-regulated in roots of the parasitic plant Triphysaria versicolor after being exposed to the haustorium-inducing molecule 2,6-dimethoxybenzoquinone (DMBQ).

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In human and murine embryonic development, haematopoiesis and B-lymphopoiesis show stepwise differentiation from pluripotent haematopoietic stem cells and multipotent progenitors, over lineage-restricted lymphoid and myeloid progenitors to B-lineage committed precursors and finally differentiated pro/preB cells. The questionnaire results were compared between the aboriginal and nonaboriginal children.

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Hepatocytes express aquaporins, a family of membrane channel proteins that facilitate the osmotically-driven movement of water molecules. Generation of ortho-SF5-Benzyne and Its Diels-Alder Reactions with Furans: Synthesis of 1-SF5-Naphthalene, Its Derivatives, and 1,6(1,7)-Bis-SF5-naphthalenes. Use of hearing impairment (HI) questionnaires has been an alternative to formal audiometry.

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Our results implicate ABCB4 as a major determinant of diet-induced hypercholesterolemia in high-responding opossums and suggest that other genes interact with ABCB4 to regulate lipemic response to dietary cholesterol. externally-cued learning on the permanent storage of a schema by retardates.

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Calibration and calibration transfer methodologies have been discussed to enhance the applicability of electronic nose system. Practical issues regarding angular and energy response in in vivo intraoperative electron radiotherapy dosimetry.

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These evidence-based care guidelines were presented at the 10th International Meeting of PCICS and have been utilized in the preparation of this article. Vitamin D levels in children affected by vernal keratoconjunctivitis. Further study demonstrated that the upregulation of cyclin D1 and cyclin E2 complexes, along with a compromised G(2)/M transition due to the decreased CDK1 (cyclin-dependent kinase 1) activity and upregulated p21, contributed to the mutant cell S-phase arrest and eventually led to the retarded cell growth. The method of texture analysis presented here provides a novel way to characterize tumors, and demonstrates clear differences between cancer groups which are detectable before treatment begins, and can help with treatment planning as a valuable prognosis tool.

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It is so far not clear whether supportive postnatal environments are able to modify such prenatally-induced alterations. Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility. Catalytic Enantioselective Functionalization of Unactivated Terminal Alkenes. Sphinganine and sphingosine levels and ratio in urine and blood samples from a Catalonian population, Spain. An established gastric-carcinoma cell line, EPG85-257P, is extremely sensitive to mitoxantrone (IC50, 0.12 ng/ml).

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It was found that the affinity of melittin for lipodisks is independent of the disk size and rim charge. MPM cells express aquaporin-1 (AQP1) that in other cancers has been shown to participate in the tumor metastasis processes. Economic theories posit reward probability as one of the factors defining reward value.

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Findings are discussed in the context of feasibility issues and lessons learned for program revisions. Distinguishing isomeric aldohexose-ketohexose disaccharides by electrospray ionization mass spectrometry in positive mode. Studies of methyl aminolevulinate photodynamic therapy for actinic keratosis It is argued that this inhibition is exerted onto the interneurones mediating the non-monosynaptic excitation to motoneurones. In all 16 patients the flap survived without signs of impaired circulation.

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CRH seems to exert its effects through interaction with two known so far receptors, CRF1R and CRF2R. However, their levels other than ferritin were higher in Group 2 at the end of second month. The UW bonded chips showed a significantly superior electrochemical performance compared to the ones obtained using TB. Removal of a Nonpalpable Etonogestrel Implant With Preprocedure Ultrasonography and Modified Vasectomy Clamp. To help prevent nosocomial TB transmission a project was implemented that aimed at providing nationwide tailor-made technical assistance in TB infection control (TB-IC) in TB treatment facilities, including the development of TB infection control plans.

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Thirty-one individuals with severe mental illness were referred and 23 completed the intervention. Genetic factors appear to play a role in the aetiology of lung cancer. Double Distal Intraneural Fascicular Nerve Transfers for Lower Brachial Plexus Injuries. Intrinsic features germane to Bulbophyllum (e.g., high dispersal ability, drought tolerance, multiple photosynthetic pathways) as well as extrinsic factors (ecological, historical) likely interacted to generate the niche transition patterns observed. Therapeutic effect of CNP on renal osteodystrophy by antagonizing the FGF-23/MAPK pathway.

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After 70 patients had been randomized into 2 groups of 35 patients each, both the control and experimental groups (groups 1 and 2, respectively) were advised to take 75 mg/day of diclofenacsodiumas needed for pain relief but only the experimental group to take 4 mg/day of silodosin. This implies that poly-fused thiophenes posses novel field-effect transistor properties. The clinical significance of the carotid body (CB) has been increasing.

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The difficulties in establishing diagnosis are confirmed by the review of other reports. By immunofluorescence the cationic immune complexes deposited linearly along the glomerular basement membrane. Directly acting antivirals against hepatitis C virus: mechanisms of action and impact of resistant associated variants. Breast core biopsy revealed a proliferation of neoplastic epithelioid cells mimicking an infiltrating pleomorphic lobular carcinoma. Architectural and topographic study of the Saint-Jacques Hospital at Pelerins, in Paris, between the fourteenth and sixteenth centuries: architectural unity of the hospital complex

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Here we use greenhouse experiments to examine flood responses in plants of the Piriqueta caroliniana (Turneraceae) complex, which occupy a range of moisture regimes. In this review, we discuss recent progress in our understanding of regulation of autophagy and its crosstalk with metabolic signaling, with a focus on the nutrient-sensing mTOR complex 1 (mTORC1) pathway.

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The aim of this study was to determine the incidence and characteristics of women with fecal incontinence symptoms during early and late pregnancy, to evaluate its impact on quality of life, and to identify whether there is a specific clinical pattern that could identify patients at risk. ReCAP: Impact of Multidisciplinary Care on Processes of Cancer Care: A Multi-Institutional Study.

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Assortative mating and mutation diffusion in spatial evolutionary systems. The study design was prospective with emotional dissonance measured at baseline and then linked to official registry data of medically certified sickness absence for the year following the survey assessment.

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This study on 279 people over 75 years found 105 new cases of cognitive impairments, among which 62 cases of dementia. This study investigated the concentration of endotoxin, a substance produced by gram-negative bacteria, in contact lens cases. The contribution of a collagen-fibrin patch (Tachosil) to prevent the postoperative lymphatic complications after groin lymphadenectomy: a double institution observational study.

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Microsatellite instability is rare in small intestinal neuroendocrine tumors (NETs). A modification of the forest plot, by including an additional (vertical) axis indicating the proportion of a certain subgroup variable, is a qualitative, visual, and easy-to-interpret method to explore potential subgroup effects in studies included in meta-analyses. This article introduces a principal therapeutic modality in the treatment of psoriasis, atopic dermatitis (eczema), vitiligo, and morphea among other diseases where oral manifestations may be present, providing basic information about the use of UVA, UVB, and PUVA. Kinetic and thermodynamic determinants of trace metal partitioning at biointerphases: the role of intracellular speciation dynamics.

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By stimulating the lateral funiculus we can evoke intense synaptic activity associated with large increases in conductance of the recorded neurons. The CTA of 10 human cadaveric knee joint was measured in 3-D digital models based on MRI (group A), in 3-D digital models based on CT (group B), in the cadaveric knee joint with cartilage (group C), and in the cadaveric knee joint without cartilage (group D), respectively. The use of polysulfone dialyzers rarely causes hypersensitivity reactions.

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A description and estimate of very low-intensity activity and inactive awake time in community-dwelling adults with chronic spinal cord injury. This resembled the histopathological feature of rheumatoid arthritis (RA) when these findings are summarized. Implementation of standardized protocols for patients with CP has proven to be a cost effective strategy at several institutions across the country.

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Both patients experienced resolution of their symptoms only after minocycline discontinuation. Pharyngocutaneous fistula is a common complication of laryngectomy. Presentation of a FORTRAN program for the study of anisodiametric growth Competing Magnetic Fluctuations in Iron Pnictide Superconductors: Role of Ferromagnetic Spin Correlations Revealed by NMR.

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Repair accordingly must occur everywhere, yet it is inevitably affected by its chromatin environment. The severity of CAD was determined by the presence and extent of coronary artery stenosis. Experiments with different size amino-terminal fusion partners coupled to GFP demonstrated that the first 35 amino acids of eNOS are sufficient to target GFP into the Golgi region of NIH 3T3 cells. Diagnostic utility of glypican-3 for hepatocellular carcinoma on liver needle biopsy. Platinum coils are prone to compaction, and currently used liquid embolics are delivered with angiotoxic agents.

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We analyzed the trnL-rpl32 intergenic region of chloroplast DNA (cpDNA) obtained from 37 cultivated radish individuals from four different cultivars, 53 R. The preglomerular vasculature has a higher expression of Cxs than the postglomerular vasculature. MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1.

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Pretreatment with the synthetic glucocorticoid analogue dexamethasone followed by the administration of a single dose of reserpine completely reversed the decrease in phenylethanolamine N-methyltransferase mRNA seen after reserpine treatment alone, but had no effect on the reserpine-induced increase in tyrosine hydroxylase mRNA. Cockroach induces inflammatory responses through protease-dependent pathways. Furthermore, results from chromatin immunoprecipitation showed GATA-1 binding in vivo to the conserved region of the ETO promoter containing the -636 site. Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis.

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However, some accompanying symptoms of sarcoidosis, such as splenomegalia, did not respond. Corneal surgery in keratoconus: which type, which technique, which outcomes?

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We performed an in-depth evaluation of current eyebrow aesthetics using two study groups. Hepcidin is positively regulated by iron via the bone morphogenetic protein (BMP)-SMAD signaling pathway. Women may be induced to ovulate at any point of the menstrual cycle or even during periods of amenorrhea associated with pregnancy and lactation if exposed to an appropriate acute stressor under a right estradiol environment. The results show that frequency discrimination capacity is influenced by specific phenomena of the instrumental education.

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In this study, we propose a novel hypothesis that tension in an actin filament prevents the filament from being severed by cofilin. A crystal plasticity finite element method (CPFEM) model has been developed to investigate the mechanical properties and micro-texture evolution of single-crystal aluminum induced by a sharp Berkovich indenter.

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Myxosporean hyperparasites of gill monogeneans are basal to the multivalvulida. In this chapter we focus on basic protocols allopurinol pharmacological classification amoxicillin for characterization of lymphocytes and/or local T lymphocyte-related antigens in mouse atherosclerotic lesions. A review of ablative techniques in the treatment of breast fibroadenomata.

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A method for systematic assessment of the relative prognostic significance of symptoms and signs in patients with a chronic disease. Management of acute aortic dissections with a cylinder-type balloon catheter to close pantoprazole ratio 40 mg precious memories the entry.

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HSC3AS showed decreasing mRNA and protein levels of MMP-1, -3, and -9. Active surveillance of antimicrobial use with prednisolone moon face syndrome intervention and real-time feedback to providers and reinforcement of prior authorization for selected antimicrobials were introduced at a pediatric teaching hospital. Gabapentin significantly reduced APN median eye speed in all three planes, but baclofen did so only in the vertical plane. Visual assessment can be used for such a purpose, but its reproducibility has not been established.

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In this study, Klebsiella pneumoniae was engineered to directly produce 2-butanone from glucose by extending its native 2, 3-butanediol synthesis pathway. Coronary dissection and total coronary occlusion associated with percutaneous transluminal coronary angioplasty: significance of initial angiographic morphology of coronary stenoses. Basic questionnaire that included items related to socioeconomic status, apa itu ometac 20 capsule comorbidity, and lifestyle, and the validated Korean version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) were collected. Comprehensive hospital orientation benefits and outcomes should be visible to policy makers. Nine hundred-bed, academic, tertiary hospital in Houston, Texas.

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Injury to the posterior ligament complex, which is often encountered in patients with burst and compression fractures, can be reliably revealed by MR imaging. This case report investigated a woman with BPD who had experienced spiritual distress during nursing care. Collaboration between welfare organizations is an hydrochlorothiazide make you gain weight important strategy for integrating different health and welfare services.

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